Microbial keratitis (MK), an infection resulting in corneal ulceration, is a sight-threatening complication affecting over 30,000 people in the United States per year. MPSs containing dual biocides polyquaternium-1 and myristamidopropyl dimethylamine possessed the highest disinfection efficacy against multiple ocular pathogens. These were followed closely by RevitaLens and renu Advanced. Broadly, among the microorganisms tested, the OPTI-FREE products (Puremoist, Express, and Replenish) maintained the highest disinfection efficacies at the manufacturer’s stated disinfection time when paired with any contact lens, compared with other MPSs. The majority of MPSs demonstrated significantly higher disinfection efficacies without contact lenses.
Plates were incubated for 2–7 days and plate counts were conducted to determine the number of surviving microorganisms. In accordance with International Standards Organization protocol 1479, the microorganisms were inoculated into each MPS with and without contact lenses, and held for the manufacturer’s disinfection time, 24 h, and 7 days after challenge with Serratia marcescens or Fusarium spp. Therefore, we compare the efficacy of nine major MPSs on the global market against four different microorganism species, and with four different common contact lenses.
It is then critical to determine the efficacy of popular MPSs against ubiquitous ocular microorganisms. Thus, the patient’s choice and use of these MPSs is a known risk factor for the development of MK. These microorganisms can be introduced to the eye via improper contact lens usage or hygiene, or ineffective multipurpose solutions (MPSs) to disinfect daily wear contact lenses. Microbial keratitis (MK) is an eye infection caused by opportunistic bacteria or fungi, which may lead to sight-threatening corneal ulcers.
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